Fig. 5: Use of Ifit1 as surrogate marker reveals a negative prognostic value of Stat1-Ido1 expression in the neoplastic epithelium of CRC.
From: IDO1+ Paneth cells promote immune escape of colorectal cancer
a, b One hundred and forty-nine IHC-stained sections of human CRC were used to assess the correlation between STAT1 and IDO1 protein expression in the tumor cell compartment (a) and the stroma (b). c Scatter plot of TCGA expression data showing a strong correlation between Stat1 and Ido1 mRNA expression in human CRC. d–f Patient survival curves for Stat1high/low (d), Ido1high/low (e), and Ifitlow Stat1high/low (f) CRC using TCGA data. The median expression was used for stratification. g, h Stratification of human CRC into Ifit1low Stat1high and Ifit1high Stat1low cancer subtypes, and correlation with the tumor stage using TCGA data.
