Table 2 Novel CCT loci identified in the combined (GERA+IGGC) GWAS meta-analysis.

From: A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness

 

Combined meta-analysis

GERA

IGGC

SNV

Chr

Pos

Locus

Alleles

β (SE)

P

Q

I

β (SE)

P

β (SE)

P

rs10800558

1

170828021

PRRX1

C/A

1.38 (0.24)

6.6 × 10−9

0.30

6.67

1.09 (0.37)

0.0029

1.59 (0.31)

3.7 × 10−7

rs848546

2

36704767

CRIM1

A/G

−1.55 (0.25)

5.4 × 10−10

0.37

0

−1.81 (0.39)

2.9 × 10−6

−1.36 (0.33)

3.0 × 10−5

rs1800440

2

38298139

CYP1B1

T/C

−1.89 (0.33)

1.4 × 10−8

0.88

0

−1.83 (0.50)

0.00026

−1.93 (0.44)

1.4 × 10−5

rs880930

2

238396872

MLPH

G/C

1.58 (0.29)

2.7 × 10−8

0.34

0

1.26 (0.44)

0.0040

1.82 (0.37)

1.2 × 10−6

rs11917483

3

29393868

RBMS3

T/C

−1.66 (0.26)

1.2 × 10−10

0.92

0

−1.63 (0.39)

2.5 × 10−5

−1.68 (0.35)

1.1 × 10−6

rs62292788

3

187016877

LOC101929130

G/A

1.56 (0.25)

2.9 × 10−10

0.17

48.13

1.97 (0.38)

3.2 × 10−7

1.27 (0.32)

8.1 × 10−5

rs2320163

4

140174641

MGARP

G/C

1.59 (0.24)

3.7 × 10−11

0.94

0

1.57 (0.37)

2.0 × 10−5

1.61 (0.32)

4.3 × 10−7

rs7737693

5

52602941

FST

C/T

1.40 (0.25)

1.3 × 10−8

0.49

0

1.21 (0.37)

0.0011

1.54 (0.33)

2.4 × 10−6

rs35351529

5

79390222

THBS4

T/C

2.43 (0.44)

3.2 × 10−8

0.18

43.25

3.05 (0.64)

2.1 × 10−6

1.88 (0.60)

0.0017

rs2731646

5

121420919

LOX

A/G

1.73 (0.24)

5.2 × 10−13

0.92

0

1.76 (0.37)

1.5 × 10−6

1.71 (0.32)

7.2 × 10−8

rs154001

5

127685135

FBN2

C/T

1.54 (0.27)

8.8 × 10−9

0.067

70.21

2.08 (0.40)

1.9 × 10−7

1.10 (0.36)

0.0022

rs6459472

6

16522607

ATXN1

A/G

1.45 (0.24)

2.6 × 10−9

0.17

47.74

1.06 (0.37)

0.0040

1.74 (0.32)

6.7 × 10−8

rs9350413

6

22067279

LINC00340

T/A

−1.42 (0.25)

2.5 × 10−8

0.76

0

−1.51 (0.38)

6.9 × 10−5

−1.35 (0.35)

9.3 × 10−5

rs7749695

6

113376787

RFPL4B

T/C

1.48 (0.27)

2.7 × 10−8

0.40

0

1.76 (0.42)

2.8 × 10−5

1.30 (0.35)

0.00017

rs10124621

9

111488128

ACTL7B

G/T

−1.61 (0.27)

1.9 × 10−9

0.54

0

−1.79 (0.40)

7.5 × 10−6

−1.46 (0.36)

5.1 × 10−5

rs4623781

10

25803024

GPR158

A/T

1.35 (0.24)

1.3 × 10−8

0.45

0

1.13 (0.37)

0.0021

1.50 (0.31)

1.2 × 10−6

rs2505507

10

43644824

CSGALNACT2

C/T

1.53 (0.27)

2.1 × 10−8

0.27

18.15

1.87 (0.41)

5.7 × 10−6

1.26 (0.36)

0.00051

rs4311997

10

124179299

PLEKHA1

C/T

1.35 (0.23)

8.3 × 10−9

0.85

0

1.40 (0.36)

0.00011

1.31 (0.31)

1.9 × 10−5

rs688601

11

1891284

LSP1

T/A

−1.67 (0.30)

2.7 × 10−8

0.55

0

−1.92 (0.51)

0.00019

−1.54 (0.37)

3.3 × 10−5

rs3740685

11

47468791

RAPSN

C/T

1.50 (0.26)

5.7 × 10−9

0.77

0

1.59 (0.40)

6.0 × 10−5

1.44 (0.34)

2.3 × 10−5

rs4611262

12

102502759

NUP37

T/C

2.37 (0.30)

2.0 × 10−15

0.21

35.97

2.80 (0.45)

6.2 × 10−10

2.05 (0.40)

2.7 × 10−7

rs1176321

13

81227243

SPRY2

G/A

1.77 (0.26)

9.3 × 10−12

0.85

0

1.83 (0.39)

2.9 × 10−6

1.73 (0.35)

7.0 × 10−7

rs28667150

14

73137234

DPF3

G/A

−1.64 (0.25)

5.3 × 10−11

0.52

0

−1.83 (0.38)

1.5 × 10−6

−1.50 (0.33)

6.6 × 10−6

rs12898341

15

51456385

MIR4713HG

C/T

−1.59 (0.24)

4.2 × 10−11

0.42

0

−1.82 (0.37)

7.7 × 10−7

−1.43 (0.32)

9.0 × 10−6

rs12324079

15

79501867

ANKRD34C−AS1

T/G

−1.54 (0.24)

2.0 × 10−10

0.65

0

−1.67 (0.37)

7.0 × 10−6

−1.44 (0.32)

6.2 × 10−6

rs4785955

16

4297651

LOC100507501

G/T

1.79 (0.30)

3.3 × 10−9

0.50

0

1.57 (0.45)

0.00049

1.98 (0.41)

1.4 × 10−6

rs7211723

17

63854425

CEP112

A/C

−1.62 (0.27)

3.4 × 10−9

0.63

0

−1.77 (0.42)

2.7 × 10−5

−1.50 (0.36)

2.8 × 10−5

rs448203

17

75495065

SEPT9

T/C

1.84 (0.29)

2.1 × 10−10

0.54

0

2.01 (0.41)

7.8 × 10−7

1.66 (0.41)

5.3 × 10−5

rs11650127

17

79572253

NPLOC4

G/A

−1.96 (0.30)

4.8 × 10−11

0.49

0

−2.15 (0.40)

1.1 × 10−7

−1.73 (0.44)

8.1 × 10−5

rs13036662

20

2784053

CPXM1

G/A

−2.11 (0.38)

3.2 × 10−8

0.73

0

−1.95 (0.60)

0.0012

−2.22 (0.49)

6.8 × 10−6

21:40195541

21

40195541

ETS2

G/GT

1.46 (0.25)

7.2 × 10−9

0.27

18.75

1.78 (0.38)

3.0 × 10−6

1.22 (0.34)

0.00033

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