Fig. 2: Genomic landscape of PDX library. | Communications Biology

Fig. 2: Genomic landscape of PDX library.

From: Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors

Fig. 2

a Bar charts of somatic single-nucleotide variant (SNV) load and type, insertion/deletion (indel) load and type and structural variant (SV) load and type across PDX (n = 36) and patient tumor (n = 31) samples, which underwent whole-genome sequencing. Samples are ordered on SNV load and samples from same patient (patient tumor and PDX(s)) are adjacent to each other. b Heatmap of genome-wide copy number alteration (CNA) profiles. c Oncoprint of somatic alterations in genes previously associated with breast tumorigenesis. Sample order is the same for a–c.

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