Table 2 PAML analyses for the tcdA and tcdB genes.

From: Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B

Models

Gene

Hypothesis (model)

lnLa

p valueb

Hypothesis-testing

ωc

M1a versus M2a

tcdA

Null (M1a)

−11405.514

<0.001

Positive selection

5.889

Alternative (M2a)

−11394.345

tcdB

Null (M1a)

−18796.020

0.010

Positive selection

35.957

Alternative (M2a)

−18791.455

M8a versus M8

tcdA

Null (M8a)

−11394.667

<0.001

Positive selection

4.869

Alternative (M8)

−11405.514

tcdB

Null (M8a)

−18763.111

0.0017

Positive selection

27.059

Alternative (M8)

−18768.022

  1. aInL is the log-likelihood score.
  2. bLikelihood ratio test to detect positive selection, p < 0.05 was considered significant.
  3. cRatio of non-synonymous and synonymous substitution.
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