Table 5 Average values of the top eight biomarker features for each diagnosis group that can be used to predict cognitive status.

Aβ-Precuneus (SUV cm⁻³)

0.0873 ± 0.0231

0.107 ± 0.0272

A

Z = 5.79, P < 0.0001** r = 0.34

Z = 9.89, P < 0.0001ǂǂ r = 0.62

Aβ-Frontal (SUV cm⁻³)

0.0114 ± 0.00260

0.0129 ± 0.00286

Z = 6.75, P < 0.0001** r = 0.39

Z = 9.07, P < 0.0001ǂǂ r = 0.56

Aβ-Cingulate (SUV cm⁻³)

0.0787 ± 0.00181

0.0892 ± 0.00192

Z = 4.87, P < 0.0001** r = 0.28

Z = 8.03, P < 0.0001ǂǂ r = 0.50

Aβ-Temporal (SUV cm⁻³)

0.0302 ± 0.00678

0.0331 ± 0.00672

Z = 6.76, P < 0.0001** r = 0.39

Z = 9.92, P < 0.0001ǂǂ r = 0.62

pTau (pg ml⁻¹)

29.70 ± 14.01

38.50 ± 16.52

T

Z = 5.62, P < 0.0001** r = 0.33

Z = 9.56, P < 0.0001ǂǂ r = 0.60

FDG-Angular (SUV cm⁻³)

1.13 ± 0.149

0.956 ± 0.159

N

Z = 5.31, P < 0.0001** r = 0.31

Z = 11.46, P < 0.0001ǂǂ r = 0.71

FDG-CingulumPost (SUV cm⁻³)

2.84 ± 0.391

2.47 ± 0.343

Z = 4.72, P < 0.0001** r = 0.27

Z = 10.69, P < 0.0001ǂǂ r = 0.67

FDG-Temporal (SUV cm⁻³)

7.78 ± 0.983

6.73 ± 0.924

Z = 4.54, P < 0.0001** r = 0.26

Z = 10.82, P < 0.0001ǂǂ r = 0.67

Hippocampus volume (cm³)

6.67 ± 1.11

5.91 ± 0.923

Z = 6.62, P < 0.0001** r = 0.39

Z=10.59, p < 0.0001ǂǂ r=0.66

Entorhinal cortex volume (cm³)

3.39 ± 0.710

2.92 ± 0.622

Z = 5.51, P < 0.0001** r = 0.32

Z = 9.40, P < 0.0001ǂǂ r = 0.59