Fig. 6: αSynO binds to huPrP(23−144) with high affinity.
From: Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus
BLI sensorgrams of αSyn mono−huPrP(23−144) (a) and αSynO−huPrP(23−144) (a, b) interactions. Biotinylated huPrP(23−144) (carrying a C-terminal Cys for biotinylation) was coupled to streptavidin biosensors and αSyn was used as analyte. a Comparison of binding of αSyn mono and αSynO. b Concentration-dependent binding of αSynO. Association occurred from 0 to 600 s (a, b), dissociation from 600 to 1200 s (a) or 600 to 1800 s (b).
