Fig. 8: Residues important for VSD-pore coupling in KCNQ1.
From: A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation
The residues are shown as colored sticks in the cryo-EM structure of hKCNQ1 (PDB entry: 6uzz). The colors indicate residues in the classic interactions (blue, including V254, H258, A341, P343, and G345), the interactions specifically when the VSD is at the activated state (cyan, including M238, L239, D242, R243, W248, L250, L251, V255, F256, Y267, I268, L271, G272, F335, S338, F339, and L342), specific interactions with PIP2 (orange, T247, R259, Q260, and T264), specific interactions with CP1 (magenta, R249 and S253), and interactions with both PIP2 and CP1 (red, K354 and K358). a One KCNQ1 subunit. b Enlarged frame. c Enlarged frame from different views.
