Fig. 2: Both nuclear Kaiso and cytoplasmic Kaiso are predictive of poor breast cancer survival. | Communications Biology

Fig. 2: Both nuclear Kaiso and cytoplasmic Kaiso are predictive of poor breast cancer survival.

From: Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival

Fig. 2

a Analysis of the association between subcellular Kaiso distribution and survival demonstrates that high cytoplasmic Kaiso is much more predictive of poor survival compared to nuclear Kaiso. Nuclear, cytoplasmic, and total Kaiso H-scores predict survival in both b high risk (lymph node-positive) and c low risk (lymph node-negative) breast cancer patients, where total Kaiso score is most predictive of survival in both low and high-risk breast cancer patients. (HR could not be calculated for cytoplasmic Kaiso in low-risk patients because no deaths were recorded in that risk group). NHW non-Hispanic white; NHB non-Hispanic black. Optimized cut-offs were determined by the method of maximally selected rank statistics (Supplementary Fig. 3 and Supplementary Table 2).

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