Fig. 6: Patients stratified by nuclear and cytoplasmic Kaiso are variably enriched in cell stress and immune response pathways and differentially predict survival based on genetic ancestry.

a Volcano plot of differential gene expression of patients stratified by nuclear Kaiso. (Right) Gene set enrichment analysis of patients stratified by cytoplasmic Kaiso (Supplementary Data 5 and 6). b Volcano plot of differential gene expression of patients stratified by cytoplasmic Kaiso (right) Gene set enrichment analysis of patients stratified by nuclear Kaiso. c Population-specific composition of a representative portion (N = 131) of the breast cancer cohort, by genetic ancestry-based ancestry informative markers extracted from the RNA-seq data. Indicated colors reflect the percent admixture of each genetic population. d Forest plot analysis of overall survival hazard-based optimized cut-off for cytoplasmic Kaiso for the total population, NHW patients, NHB patients, and median cut-off for the total population. e Forest plot analysis of overall survival hazard-based optimized cut-off for LC3A/B in the total population, NHW patients, NHB patients, and the median cut-off for the total population. f Forest plot analysis of overall survival hazard based on optimized cut-off for nuclear Kaiso in the total population, NHW patients, NHB patients, and the median cut-off for the total population. g Forest plot analysis of overall survival hazard based on optimized cut-off for nuclear Kaiso in TNBC patients using optimized cut-off for NHW patients, NHB patients, and the median cut-off for the total TNBC population.