Fig. 7: The G1K06H1 CARTIV promotor is induced in the tumor microenvironment.
From: Synthetic promoters to induce immune-effectors into the tumor microenvironment
a Schema of the experimental setup used to test the G1K06H1 promotor in vivo. b Representative FACS plot of the RFP670 reporter of ZsGreen positive cells injected subcutaneous or intratumoral. Data are single-discriminated and DAPI-negative results. c Summary of reporter expression in the CDX compared with the Matrigel plug in 6 mice; exclusion criterion was less than 500 cells detected. Number of tested tumors is eight; a t-test was performed, box borders represent upper and lower quartiles. Solid lines represent the median and dashed line the mean. Whiskers represent maximum and minimum. *P-value < 0.05; **P-value < 0.005; ***P-value < 0.0005.
