Table 3 Pharmacokinetic profile of compound 1 and compound 5.

From: Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition

 

Exposure in plasma and brain

Plasma

(ng/mL)

Brain

(ng/g)

Kp,brain

1

869

25.4

0.029

5

7560

6025

0.80

  1. Bioisosteric compound 5 is a brain penetrant inhibitor.
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