Fig. 8: Crystal structure of the ΔASIC1/JNJ-799760 complex. | Communications Biology

Fig. 8: Crystal structure of the ΔASIC1/JNJ-799760 complex.

From: Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

Fig. 8

a Architecture of ΔASIC1/JNJ-799760 viewed parallel to the membrane. One subunit is highlighted with a different color for each domain. JNJ-799760 is in yellow. b The same structure viewed extracellularly with each subunit in a different color. c Stereo view of the JNJ-799760-bound ECD (chain A). Key α helixes and β sheets are labeled. The 2Fo−Fc electron density map of JNJ-799760 contoured at 1.0σ is shown as blue mesh. d Stick representation of JNJ-799760 and the surrounding channel residues in the binding pocket (chain A). Numbers next to the dotted lines indicate distances (in Å). Oxygen and nitrogen atoms are shown in red and blue, respectively.

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