Fig. 8: Genome-wide homozygosity association study.
From: Genetic ancestry plays a central role in population pharmacogenomics
The results of genome-wide homozygosity association tests for each of the five studied continental ancestry groups (AFR, AMR, EAS, EUR, and SAS) and for a comparison of the five continental ancestry groups in the whole-continental group (whole-continents) are shown in Manhattan plots. The vertical axis represents the P values (–log10 scale) of the homozygosity association tests based on a two-sided Kruskal–Wallis test. The horizontal axis represents the physical positions of the anchor SNPs of sliding windows by chromosome. A red reference line indicates a P value threshold of a Bonferroni multiple-testing correction. Quantile–quantile plots (Q–Q plot) are provided on the right-hand side. Sample size n = 2504 individuals.
