Table 1 Global distributions of AIMs.
From: Genetic ancestry plays a central role in population pharmacogenomics
Ancestry groups | VarType | # of SNVs | # of AIMs based on allele-based 2-sided Fisher exact test (the proportion of AIMs, PAIM) |
|---|---|---|---|
False discovery rate | |||
ALL | MAF = 0 | 245,462 | - |
SNP | 5,533,074 | 5,506,536 (99.520%) | |
RV | 58,354,524 | 7,264,275 (12.449%) | |
SNP/RV | 13,685,123 | 13,677,393 (99.944%) | |
Total SNV* | 77,572,721 | 28,531,199 (36.780%) | |
AFR | MAF = 0 | 38,873,037 | - |
SNP | 10,326,460 | 2,530,827 (24.508%) | |
RV | 16,020,578 | 0 (0%) | |
SNP/RV | 12,598,108 | 2,711,122 (21.520%) | |
Total SNV* | 38,945,146 | 3,831,696 (9.839%) | |
AMR | MAF = 0 | 51,903,729 | - |
SNP | 7,032,091 | 3,698,704 (52.597%) | |
RV | 12,632,724 | 0 (0%) | |
SNP/RV | 6,249,639 | 459,185 (7.347%) | |
Total SNV* | 25,914,454 | 3,602,015 (13.900%) | |
EAS | MAF = 0 | 56,021,288 | - |
SNP | 6,271,954 | 1,457,317 (23.235%) | |
RV | 11,680,819 | 0 (0%) | |
SNP/RV | 3,844,122 | 750,456 (19.522%) | |
Total SNV* | 21,796,895 | 1,501,008 (6.886%) | |
EUR | MAF = 0 | 55,685,350 | - |
SNP | 7,161,303 | 854,478 (11.932%) | |
RV | 10,956,920 | 0 (0%) | |
SNP/RV | 4,014,610 | 417,108 (10.390%) | |
Total SNV* | 22,132,833 | 834,331 (3.770%) | |
SAS | MAF = 0 | 53,228,676 | - |
SNP | 7,239,212 | 217,333 (3.002%) | |
RV | 12,766,736 | 4 (0.000031%) | |
SNP/RV | 4,583,559 | 187,916 (4.100%) | |
Total SNV* | 24,589,507 | 172,096 (0.700%) |
