Fig. 4: The structures of Nsp15 endoribonuclase with bound ligands.
From: Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2
A 5′UMP in light green, B 5′GpU in teal, C 3′UMP in gray, D Tipiracil in yellow, and E uridine 2′,3′-vanadate in light coral. Phosphate ions are in orange/red. F Ligands electron density omit maps contoured at 3.2 σ except for the map for GpU which was contoured at 2.5 σ.
