Fig. 6: PRC2-bound silencers and their target TSSs are enriched in the TssBiv and ReprPC states.
From: Annotation of chromatin states in 66 complete mouse epigenomes during development
a Percentage of PRC2-bound silencers whose centers overlap a genomic bin assigned to the TssBiv, Tss, ReprPC, or other chromatin states. Silencers were divided into four groups by Ngan et al.33 according to H3K27ac signals in mouse fetal tissue biosamples. To normalize for the differential genomic coverage of the chromatin states, matching numbers of genomic bins were randomly drawn from the other states to match the number of genomic bins in TssBiv in each biosample. States are colored as in Fig. 1b and the average of the other 15 states is shown as a gray dashed line. b Same as a but for the TSSs targeted by the PRC2-bound silencers defined by Ngan et al.33. We randomly selected TSSs with the same distance distribution from PRC2-bound silencers as a control (open boxplots).
