Fig. 1: Flowchart of the analyses performed in this study.

Each box represents either a set of data or an analysis performed in this study. Green boxes highlight GWAS analyses, while the rest are post-GWAS investigations. The analyses presented in pink boxes employ both data from the current GWAS as well as publicly available data. Orange clusters represent analyses performed to achieve an overall task. GW-Sig genome-wide significant, Sugg-Sig suggestive significant, TWAS transcriptome-wide association analysis, eQTL expression quantitative trait loci, PRS Polygenic Risk Score, UKB UK Biobank. Details for the 11 GW significant and 6 suggestive-significant loci are provided in Tables 1 and 2.