Fig. 3: Expression quantitative trait locus transcriptional effects for MacTel risk alleles (SNPs) across six tissue types. | Communications Biology

Fig. 3: Expression quantitative trait locus transcriptional effects for MacTel risk alleles (SNPs) across six tissue types.

From: Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

Fig. 3

The averaged effects of all proximal SNPs on gene expression across tissue subtypes are represented as coloured points. As the primary disease site, retina is represented as a larger dot for ease of identification. The mean eQTL effect by tissue type is represented on x-axis while gene symbols are represented on the y-axis. Numbers in brackets denote the number of tissues in which significant eQTL were detected. Genes are ordered by the sum of tissues in which altered expression is inferred in MacTel. Genes are divided in either positive or negative global regulation defined as the average ‘|' of eQTL effect across the six tissue groups. *Effect on these genes was detected via trans-eQTL analysis in eQTLGen database.

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