Table 2 Novel suggestive-significant MacTel loci.

From: Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

Rsid

Chr

BP

Effect/non-effect allele

EAF cases

EAF controls

Cytoband

Odds ratio

95% CI

P value

P value Eur

rs2120770

1

212509005

C/A

0.179

0.218

q32.3

0.717

0.63–0.82

1.55 × 10−06

9.49 × 10−06

rs1260326

2

27730940

C/T

0.511

0.589

p23.2

0.742

0.66–0.83

1.32 × 10−07

5.67 × 10−07

rs1973480

6

74511980

G/A

0.342

0.295

q13

1.33

1.18–1.5

3.35 × 10−06

3.68 × 10−06

rs2954021

8

126482077

G/A

0.442

0.519

q24.21

0.75

0.67–0.84

2.65 × 10−07

2.28 × 10−07

rs2984814

11

31554964

T/G

0.259

0.325

p13

0.755

0.67–0.85

2.40 × 10−06

1.87 × 10−06

rs11077850

17

74661436

C/T

0.255

0.18

q25.1

1.38

1.21–1.58

1.12 × 10−06

1.58 × 10−06

  1. Novel suggestive-significant MacTel loci. The table presents the most significant SNPs reaching suggestive significance (P < 5 × 10−6) at each locus. All listed genes are covered by the haplotype (as defined by FUMA, based on linkage disequilibrium using the 1000 Genomes Project Europeans). Chr chromosome number, BP base pairs, EAF effect allele frequency, Eur European-only sample subset. This table is duplicated in Supplementary Data 18.
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