Table 3 Association of carriage of 2 versus 1 or 0 APOL1 variant alleles with opportunistic infection in four HIV cohorts, recessive model.

From: APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection

Cohort

APOL1 2 variant alleles carriers/O+, N (%)

APOL1 2 variant alleles carriers/OI−, N (%)

APOL1 2 variant alleles carriers ORraw (95% CI)

Praw

APOL1 2 variant alleles carriers ORadjusted (95% CI)

Padjusted

Other factors among tested predicting of OI OR (95% CI), P OR (95% CI), P

ART

HIV viral load

ALIVE

3/77 (3.9)

44/363 (12.1)

0.29 (0.08–0.97)

0.040a

0.29 (0.087–0.980)a

0.046a

2.03 (1.10–3.72), 0.023

1.61 (1.12–2.32), 0.011

LSOCA

34/485 (7.0)

31/299 (10.4)

0.65 (0.39-1.09)

0.09b

0.65 (0.38–1.09)b

0.10b

1.27 (0.83–1.94), 0.26

1.14 (1.02–1.28), 0.019

WIHS

19/160 (11.9)

7/32 (21.9)

0.48 (0.18–1.26)

0.0.13c

0.31 (0.096–0.977)c

0.046c

0.04 (0.005–0.29), 0.0017

1.76 (1.04–2.97), 0.036

MACS

15/135 (11.1)

79/516 (15.3)

0.58 (0.29–1.17)

0.13d

0.41 (0.14–1.20)d

0.10d

0.22 (0.12–0.39), 0.0001

1.68 (1.22–2.31), 0.0014

Meta-analysise

71/857 (8.3)

161/1190 (13.5)

0.56 (0.39–0.81)

0.002

0.50 (0.33–0.76)

0.001

0.50 (0.14–1.72), 0.27

1.45 (1.12–1.89), 0.006

Meta-analysis w/o ALIVE

68/780 (8.7)

117/827 (14.2)

0.60 (0.41–0.88)

0.008

0.64 (0.45–0.91)

0.006

0.28 (0.05–1.44), 0.13

1.42 (1.03–1.96), 0.03

  1. Note: Covariates available from each cohort were used for adjustment in the logistic regression model:
  2. aAdjusted for age, sex, ART, PCA 1–5, and HIV viral load.
  3. bAdjusted for ART, age, sex, and HIV transmission routes; PCA not available.
  4. cAdjusted for age, ART, OI, PCA 1–5 from GWAS data, HIV viral load.
  5. dAdjusted for age, ART, OI prevention, HIV viral load; PCA not available.
  6. eMeta-analysis using RevMan 5 with a random-effects model; heterogeneity test: Pq-statistic ≥0.49, I2 = 0.0%, for raw or adjusted analysis. For other leave-one-out metaanalyses, see Supplementary Table 1.
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