Fig. 6: Model of transcriptional repression of PTEN.
From: NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
The NOTCH and PRC2/EZH2 pathways form a regulatory loop where both can feed into the transcriptional repression of PTEN. Mutation or translocation of NOTCH1 or NOTCH2 leads to upregulation of HES-1/HEY-1 and PRC2/EZH2; however, NOTCH mutation is not required for EZH2 activity or transcriptional repression. EZH2 signaling can also upregulate NOTCH38. PRC2/EZH2 adds the H3K27Me3 mark of transcriptional repression (purple dots), and binds with the HES-1 transcription factor on the PTEN promoter leading to repression. Numbers 1 and 2 in black boxes represent exons of PTEN.
