Fig. 4: Genes related to Type I interferon signaling are upregulated in juvenile macaques compared to old macaques during COVID-19-infection. | Communications Biology

Fig. 4: Genes related to Type I interferon signaling are upregulated in juvenile macaques compared to old macaques during COVID-19-infection.

From: IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Fig. 4

The top 20 most significantly a upregulated genes and b downregulated genes in SARS-CoV-2 infected juvenile macaque lungs but not in old macaques. Expression values are visualized by Z scores of normalized expression data (FPKM) per sample, and Log2 Fold Change and -Log P values are from the DESeq2 output. Genes are sorted by P value. c The relative gene expression of ACE2 and ADAM17 among naive, juvenile and old SARS-CoV-2-infected macaques.

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