Fig. 3: Identification of Lin28 residues possibly involved in the cooperative association of Lin28 and YB-1 to ssDNA and RNA. | Communications Biology

Fig. 3: Identification of Lin28 residues possibly involved in the cooperative association of Lin28 and YB-1 to ssDNA and RNA.

From: Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

Fig. 3

a Two-dimensional 1H-15N HSQC spectra of Lin28-CSD interacting with 20 nt-long poly(C) oligonucleotides in the presence of increasing concentrations of YB-1-CSD, as indicated. b Upper panel: CSPs of 15N-Lin28-CSD or 15N YB-1-CSD interacting with 20 nt-long poly(C) oligonucleotides in the presence of YB-1-CSD and Lin28-CSD, respectively. Lower panel: View on YB-1 and Lin28 CSDs showing the residues experiencing CSPs.

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