Fig. 7: Putative functional consequences of a cooperative association of Lin28 to YB-rich mRNPs.
a Correlation (Pearson correlation coefficient) of the expression levels of Lin28 with 48 RBPs abundantly expressed in all human tissues46 such as YB-1 based on RNA-Seq data. b Expression levels of YB-1 and YB-2, the two most expressed Y-box-binding proteins expressed in embryo, Lin28 and Lin28b, and other RBPs, as measured during different stages of embryogenesis47. c Schematic representation of the Lin28 possible functions in cells. (I) The demixing between YB-1 and most RBPs prevents the access of RBPs to YB-1-packaged mRNPs. (II) Lin28 can bind to YB-1-packaged mRNA thanks to its cold-shock domain. (III) Putative outcomes of the binding of Lin28 to mRNPs: activation of translation (glucose metabolism, etc.) or translation repression (membrane proteins, etc.). (IV) Zoom in on the structure leading to the cooperative binding of Lin28 and YB-1 to mRNA. The percentage of Lin28a RNA targets were obtained from published data2.
