Fig. 2: Expression of miRNA detected in the thalamus of prion M1000 infected and uninfected mice at week 3, 13 and terminal stage. | Communications Biology

Fig. 2: Expression of miRNA detected in the thalamus of prion M1000 infected and uninfected mice at week 3, 13 and terminal stage.

From: Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease

Fig. 2

A Hierarchical clustering of abundantly expressed miRNA (min > 10 RPM across in all samples) in M1000 infected mice at week 3, 13 and terminal stage. B Circos plot depicting the significant DE miRNAs (min > 10 RPM across all samples, ANOVA p-value < 0.05, corrected with Benjamini-Hochberg, fold change < −1.5 and >1.5) in M1000 infected mice compared to uninfected mice. The outermost track shows miRNAs that are DE in week 3, week 13 and terminal stage of disease. The red asterisks indicates those also found DE in serum EVs. The inner tracks illustrate expression heat map across all miRNAs in the time course study. The expression levels are represented in Log2 fold change. The ribbons inside the circos plot represent biological pathways the miRNA is involved in including prion diseases, MAPK (mitogen-activated protein kinase) signalling, protein processing in endoplasmic reticulum, endocytosis and axon guidance. C Longitudinal analysis of the DE miRNAs across week 3, 13 and terminal stage. *indicates the time-point which the miRNA was found to be significantly DE (ANOVA p-value < 0.05). Prion M1000 infected; week 3 (n = 4), week 13 (n = 4) and terminal (n = 5). Uninfected; week 3 (n = 5), week 13 (n = 5) and terminal (n = 5).

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