Table 1 Demographics of human clinical patients by study group.
Codon 129-PrPres subtype | sCJD M/M | sCJD V/V | sCJD M/V | sCJD unknown | Controls (M/M or M/V or unknown) |
|---|---|---|---|---|---|
Training cohort | |||||
n | 14 | 12 | – | – | 20 |
Female | 5 | 7 | – | – | 8 |
Male | 9 | 5 | – | – | 12 |
Mean age (years) | 70·1 | 61.8 | – | – | 64.3 |
SD age (years) | 8.4 | 10.0 | – | – | 14.7 |
Biochemical subtype (Type 1/Type 2)a | 14/0 | 12/0 | – | – | 5/- |
Clinical duration (months) | 2–5 | 2–15 | – | – | N/A |
14-3-3 positive (WB or ELISA)a | 9 | 6 | – | – | N/A |
Validation cohort | |||||
n | 15 | 3 | 1 | 1 | 6 |
Female | 10 | 2 | 1 | 1 | 3 |
Male | 5 | 1 | 0 | 0 | 3 |
Mean age (years) | 68.4 | 67 | 56 | 70 | 62 |
SD age (years) | 9.4 | 6 | N/A | N/A | 9.8 |
Biochemical subtype (Type 1/Type 2)a | Unknown | Unknown | Unknown | Unknown | Unknown |
Clinical duration (months) | 1–17 | 4.1–10 | 25 | 3 | N/A |
14-3-3 positive (WB or ELISA)a | 13 | 2 | – | – | N/A |
