Fig. 4: Human and murine KP ADCs display a tumor cluster specifically associated with harboring KRAS mutations.
From: Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer
a Heatmap of the common differentially expressed genes in both murine (upper panel) and human (lower panel) KRAS-mutated ADCs, as defined by differential gene expression analysis. Row-scaled z scores of the log2-normalized expression values per gene are shown. b–c SPRING plots showing the common signature enrichment score for C10 clusters, calculated for each cell equivalent to the number of detected genes from the common signature shown in a. For the positive/upregulated (4b) and the negative/downregulated signature (4c) the more genes detected per cell, the stronger the enrichment score, represented as a scale from 0 (gray) to 0.5 (blue) to 1 (red), where an enrichment score of 1 signifies detected expression of all marker genes within that cell. SPRING plots showing a visual representation of the log2-normalized gene expression for the selected d, upregulated, and e downregulated genes of interest in both murine (left panels) and human (right panels) C10 clusters. f IPA analysis showing common top three enriched pathways in KP and Human C10s.
