Fig. 1: Vitamin B6 deficiency induces glucose intolerance during pregnancy. | Communications Biology

Fig. 1: Vitamin B6 deficiency induces glucose intolerance during pregnancy.

From: Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

Fig. 1

Body weights (A) and fasting glucose levels (B) were measured in control and vitamin B6 deficient (VB6D) non-pregnant, pregnant, and 3 weeks postpartum mice. Glucose time graphs are shown for each timepoint GD 9.5 (C), GD 12.5 (D), and GD 16.5 (E) in which VB6D dams are glucose intolerant. Glucose area under the curve (AUC) was elevated in VB6D mice only during pregnancy (F). Data represent 3–8 mice per treatment group. Analysis of panels A, B, and F were done by an unpaired, two-sided, t-test. Panels C–E by two-way, repeated-measures ANOVA. In panels D and E, diet × time interaction effect was observed, and post hoc Tukey’s tests were performed. *p ≤ 0.05, **p ≤ 0.01.

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