Fig. 5: Comparison of CNVs, nonsynonymous mutations, and the number of clones.
From: Genomic landscape of extraordinary responses in metastatic breast cancer
a Correlation between total size of CNVs and nonsynonymous mutations. Correlation between number of clones and b nonsynonymous mutations and c total size of CNVs. d Comparison of the number of clones between responders and non-responders. e The number of clones increased in patients with both higher numbers of nonsynonymous mutations and larger CNVs. The color variation from black to light gray indicates higher to lower clone numbers, respectively. The suggested cut-off of each feature for distinguishing extreme responders from non-responders is marked with yellow line. The copy number burden has more discriminative power than various feature combinations owing to the high coefficient of variation (nonsynonymous mutations: 0.97, CNV: 1.11, clone: 0.94).
