Fig. 4: Characterization of the NC-RNA density layer.
From: CryoET structures of immature HIV Gag reveal six-helix bundle
a Radial density profile of the Gag lattice. Top panel shows a tomographic slice of GagΔMAT8I lattice domain organization where CANTD, CACTD and NC-RNA density layers are coloured in blue, orange and pink, respectively. Graph shows the radial density profiles of GagΔMAT8I particles of similar size (n = 3). Black line indicates the average intensity while blue lines depict the individual particle profiles. Density profile peaks corresponding to CANTD, CACTD and NC-RNA are shaded with the same colour scheme as in the top panel. (b) Top view from density map of six-helix bundle and the NC-RNA layer, overlaid with two plausible NC-RNA (ѱ SL2 loop) models, in red and pink, fitted into the density, leaving the remaining NC-RNA density unmodeled. c, d Enlarged side view from density map in (b).
