Fig. 6: Stemness phenotypes are transcriptionally diverse.
From: Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
a Plot showing the distribution of differentially expressed genes following Brca1 deletion by infection with Ad-Cre. Each point corresponds to a single gene. Selected genes related to stemness and/or the EMT are highlighted on the plot. Dashed lines correspond to significance criteria (absolute log fold change >0.5, p < 0.05). b GSEA results for selected gene sets enriched in differentially expressed genes following Brca1 deletion. All gene sets are significantly enriched (p < 0.05) and NES values are shown. c Inferred pathway activity in control and Snail-overexpressing mOSE cells. P-values were computed from the t statistic of a linear regression model and were adjusted using the Benjamini–Hochberg FDR method. d UpSet plot showing overlaps in differentially expressed genes between all conditions assessed ranked by the condition/overlap with the largest number of genes. e Plots showing the number of assessed conditions that genes are either activated or repressed in. Selected genes are listed and putative stemness markers are underlined.
