Fig. 9: Model for splicing-mediated adaptive stress responses.
From: Overlapping roles of spliceosomal components SF3B1 and PHF5A in rice splicing regulation
Abiotic stress affects global gene expression by reprogramming it at the transcriptional and post-transcriptional levels. Plants perceive stress signals through multiple integrated signaling pathways, which regulate transcription and splicing processes. Transcription factors affect the expression of splicing factors, and in turn splicing factors regulate the splicing patterns of transcription factors. Splicing inhibitors (e.g., GEX1A) inhibit the splicing and activate the stress signaling in plants. The splicing factor protein variants insensitive to GEX1A (e.g., SGR4) impede the inhibitors’ effects of splicing inhibitors. Stress-modulated transcripts and splice isoforms help plants to cope with abiotic stresses. Arrows indicate activation or repression, and T-bars indicate repression. CS constitutive splicing, ES exon skipping, 5′ SS 5′ splice site, 3′ SS 3′ splice site, IR intron retention.
