Fig. 5: The combination, but not individuals, significantly inhibits NLRP3 inflammasome activation in LPS/ATP-stimulated RAW264.7 macrophages. | Communications Biology

Fig. 5: The combination, but not individuals, significantly inhibits NLRP3 inflammasome activation in LPS/ATP-stimulated RAW264.7 macrophages.

From: Structural analogues in herbal medicine ginseng hit a shared target to achieve cumulative bioactivity

Fig. 5

Immunostaining assay for activated NLRP3 (a) and western blot assay for determining protein expressions: b NLRP3, c NEK7, d ASC, e cleaved caspase-1/caspase-1, f cleaved IL-1β /IL-1β, g IL-18 in cell lysates. GAPDH was used as the loading control. All data are expressed as mean ± SD (n = 3). Compared with Mod, *P < 0.05, **P < 0.01, ***P < 0.001; compared with Com, #P < 0.05, ##P < 0.01, ###P < 0.001.

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