Fig. 7: The proposed model of ApoJ/SOAT2 axis in stress-induced hepatosteatosis. | Communications Biology

Fig. 7: The proposed model of ApoJ/SOAT2 axis in stress-induced hepatosteatosis.

From: Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses

Fig. 7

In hepatocytes facing stress, ApoJ mobilizes along with dispersed Golgi to the Golgi–ER contact site, where ApoJ interacts with ER-resident SOAT2 at the N-terminal IDR region and coordinates Chol esterification to produce CE for LD deposition and lipoprotein loading.

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