Fig. 5: Tumor-specific gene expression in endothelial cells. | Communications Biology

Fig. 5: Tumor-specific gene expression in endothelial cells.

From: Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile

Fig. 5

a UMAP plot of cells from G-Smo and M-Smo tumors combined with cells from P7 WT cerebella, analyzed using the Harmony algorithm. The blue circle shows the region where neural progenitor-like tumor cells and CGNPs localize. The pink circle shows the GABAergic interneuron lineage. Stromal cell types are identified by the expression of the indicated, color-coded markers. b UMAP showing endothelial cells from G-Smo, M-Smo, and P7 WT, with clusters color-coded. c genotype color-coded on the UMAP from b. Circles indicate the positions of the clusters. d Comparison of the indicated cluster populations in G-Smo, M-Smo, and P7 WT. Student’s test was used in d. Dots represent values for individual replicates, bars indicate the means and whiskers indicate the SEM. e–g Feature plots on UMAP from b, showing expression of e endothelial markers Cldn5 and Pecam1, f Cluster E0 markers Apln and Aplnr, or g tumor-specific Cluster E1 markers Abcb1a (aka Mdr1), Cxcl12, and Flt1.

Back to article page