Fig. 4: Clinical follow-up of regenerating neo-corneas after CLP-PEG and CLP-PEG-MPC implantation into post-alkali burned mini-pig corneas. | Communications Biology

Fig. 4: Clinical follow-up of regenerating neo-corneas after CLP-PEG and CLP-PEG-MPC implantation into post-alkali burned mini-pig corneas.

From: Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Fig. 4

a Corneal haze increased in response to alkali burn and surgery in CLP-PEG (black circles) and CLP-PEG-MPC (pink squares) but diminished over the 12-month follow-up period. b Corneal blink response measured by Cochet-Bonnet aesthesiometry showing immediate decrease post-surgery in CLP-PEG-MPC (pink squares) and CLP-PEG (black circles) with recovery to pre-operative levels by 12 months. Unoperated eyes (aqua triangles) do not show changes in the blink response. c CLP-PEG-MPC (pink squares) grafts resulted in a corneal thickness comparable to the unoperated eye (aqua triangles), but CLP-PEG (black circles) resulted in significant increases in corneal thickness. d Schirmer’s tear tests showing a decrease in tear production immediately post-burn due to trauma, followed by a normal tear production in CLP-PEG-MPC (pink squares) and CLP-PEG (black circles) compared to unoperated controls (aqua triangles). e Intraocular pressure was maintained within normal parameters CLP-PEG-MPC (pink squares), CLP-PEG (black circles) and unoperated (aqua triangles) corneas throughout all stages of follow-up. Data displayed as mean ± SEM. Statistical analyses by two-way repeat measures ANOVA with Geisser’s Greenhouse correction and a Tukey’s or Sidak multiple comparison test. *Unoperated vs CLP-PEG, p<0.05. †Unoperated vs. CLP-PEG-MPC, p<0.05. ‡ CLP-PEG vs. CLP-PEG-MPC, p<0.05. For all charts the unit of analysis is the eye: CLP-PEG n=4, CLP-PEG-MPC n=4, unoperated n=8.

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