Fig. 5: Regenerated mini-pig neo-corneas at 12 months after post-CLP-PEG-MPC implantation compared to CLP-PEG and controls. | Communications Biology

Fig. 5: Regenerated mini-pig neo-corneas at 12 months after post-CLP-PEG-MPC implantation compared to CLP-PEG and controls.

From: Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Fig. 5

a–c Hematoxylin and eosin staining of the implanted corneas shows morphological similarity of the regenerated epithelium (rE) and stroma (rS) to the epithelium (E) and stroma (S) of an unoperated, healthy control cornea. The unoperated endothelium (arrowheads) remained intact in all samples. d–f Positive Ulex Europaeus Agglutinin lectin staining shows the presence of a tear film in both regenerated corneas and the control. g–i Terminally differentiated corneal cells were cytokeratin 3/76-positive in both regenerated neo-corneas. j–l Collagen V staining of the neo-cornea stromas shows the regeneration of corneal specific ECM components. Black scale bars, 500 µm; white scale bars, 200 µm.

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