Table 1 Characterization of CLP-PEG-MPC hydrogels compared to CLP-PEG only hydrogels, biosynthetic implants currently in patients and the human cornea.

From: Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

 

CLP-PEG-MPC

CLP-PEG

Biosynthetic implantsa

Human cornea

Tensile strength (MPa)

0.022 ± 0.004

0.56 ± 0.21

0.286 ± 0.0619

3.81 ± 0.4048

Elongation (%)

59.50 ± 7.70

49.96 ± 8.10

20.149 ± 7.61419

N/A

Young’s modulus (MPa)

0.044 ± 0.010

0.150 ± 0.015

1.749 ± 0.78219

3-1349, 50

Storage modulus (G′) (kPa)

15.15 ± 1.086

22.36 ± 1.489

Loss modulus (G″) (kPa)

0.1522 ± 0.0569

0.0433 ± 0.006

– 

Transmission (%)

29-80(UV) 80-97(Vis)

32-92(UV) 92-99(Vis)

95.1 ± 0.0519

87.1 ± 2.0 (at 500 nm)51

Refractive index

1.340 ± 0.005

1.338 ± 0.004

1.3507 ± 0.001152

1.423–1.43653

Water content (%)

90.94 ± 0.78

92.67 ± 0.85

91.5 ± 0.919

7854

Residual mass (%) from collagenase Degradation at 48 h

100.17 ± 3.54

96.19 ± 1.89

<10%52

  1. aRHCIII implants that have been stably grafted into 10 patients and showed regeneration at 4 years post-operation as reported in Fagerholm et al.19 The n=3 technical replicates per group for CLP-PEG-MPC, CLP-PEG and biosynthetic implants. Human cornea n-value varies by study.