Table 1 Characterization of CLP-PEG-MPC hydrogels compared to CLP-PEG only hydrogels, biosynthetic implants currently in patients and the human cornea.
CLP-PEG-MPC | CLP-PEG | Biosynthetic implantsa | Human cornea | |
|---|---|---|---|---|
Tensile strength (MPa) | 0.022 ± 0.004 | 0.56 ± 0.21 | 0.286 ± 0.0619 | 3.81 ± 0.4048 |
Elongation (%) | 59.50 ± 7.70 | 49.96 ± 8.10 | 20.149 ± 7.61419 | N/A |
Young’s modulus (MPa) | 0.044 ± 0.010 | 0.150 ± 0.015 | 1.749 ± 0.78219 | |
Storage modulus (G′) (kPa) | 15.15 ± 1.086 | 22.36 ± 1.489 | – | – |
Loss modulus (G″) (kPa) | 0.1522 ± 0.0569 | 0.0433 ± 0.006 | – | – |
Transmission (%) | 29-80(UV) 80-97(Vis) | 32-92(UV) 92-99(Vis) | 95.1 ± 0.0519 | 87.1 ± 2.0 (at 500 nm)51 |
Refractive index | 1.340 ± 0.005 | 1.338 ± 0.004 | 1.3507 ± 0.001152 | 1.423–1.43653 |
Water content (%) | 90.94 ± 0.78 | 92.67 ± 0.85 | 91.5 ± 0.919 | 7854 |
Residual mass (%) from collagenase Degradation at 48 h | 100.17 ± 3.54 | 96.19 ± 1.89 | <10%52 | – |