Fig. 2: LepR+ MSCs contribute to endochondral ossification during embryonic and postnatal growth. | Communications Biology

Fig. 2: LepR+ MSCs contribute to endochondral ossification during embryonic and postnatal growth.

From: PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation

Fig. 2

a, b Immunofluorescence shows overlapping of Tomato+ and the expression of Runx2, Osterix, collagen X, MMP13, alkaline phosphatase, cleaved caspase 3 and LepR in POC (E18.5) and SOC (P15) of Lepr-cre; tdTomato mice. Arrowheads indicate the overlapping of Tomato+ and the expression of indicated markers. HZ = Hypertrophic zone; POC = Primary ossification center; SOC = Secondary ossification center; ColX=collagen X; ALP = alkaline phosphatase; cleaved Casp 3=cleaved caspase 3. Scale bar, 100 μm.

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