Fig. 3: Transcription-centered interaction loops captured by H3K27ac Hi-ChIP.

a The stack plot shows the proportion of H3K27ac within both, one, or neither anchors. b The proportion of E–E (enhancer–enhancer), E–P (enhancer–promoter), P–P (promoter–promoter) interactions in HiChIP profile. c Virtual 4C profile at IRS2 or BIN1 locus with GR, H3K27ac signal with or without DEX treatment. The yellow bar highlights the promoter of IRS2 or BIN1. Gray bar highlights the GR sites.