Fig. 1: Metabolite homeostasis and protein homeostasis in Alzheimer’s disease (AD). | Communications Biology

Fig. 1: Metabolite homeostasis and protein homeostasis in Alzheimer’s disease (AD).

From: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

Fig. 1

a AD is associated with a wide range of dysfunctions in cellular homeostasis (colored boxes). A variety of endogenous metabolites are involved in regulating these cellular processes (gray box insets). b Small molecule endogenous metabolites can modulate the protein aggregation processes associated with the disease. By designing systematic studies we can uncover the exact molecular mechanisms by which they balance protein homeostasis.

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