Fig. 2: Identification of endogenous metabolites as protein homeostasis regulators that are dysregulated in AD. | Communications Biology

Fig. 2: Identification of endogenous metabolites as protein homeostasis regulators that are dysregulated in AD.

From: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

Fig. 2

a Schematic of the computational fragment-based strategy that we used to identify endogenous metabolites from the Human Metabolome Database (HMDB) as candidate protein homeostasis regulators that are also dysregulated in AD. b Using this approach, we identified six candidate metabolites that serve as protein homeostasis regulators (Table 1, Supplementary Fig. 1 and Supplementary Data 1).

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