Fig. 2: ARHI risk for rare variants and a common variant GRS. | Communications Biology

Fig. 2: ARHI risk for rare variants and a common variant GRS.

From: The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis

Fig. 2

a The fraction of individuals with mild (gray), moderate (orange), and severe (red) hearing impairment in the DHS dataset (N = 11,484) among the 4.9% of subjects that are carriers of any of the 16 rare ARHI variants (dots) and the 95.1% that are not carriers (squares), shown for different age groups. The corresponding dashed lines are polynomial regression lines of best fit. b The risk of ARHI for each GRS decile compared to the bottom decile expressed in ORs. The ORs from the DHS dataset (4140 cases and 7344 controls) are represented with red dots and the ORs from the NIHSI dataset (9619 cases and 298,609 controls) are represented with purple dots. The gray lines represent 95% confidence intervals. The dashed line is the reference for the bottom GRS decile (OR = 1). c The fraction of individuals with ARHI among subjects in the DHS dataset (N = 11,484) in the bottom GRS decile in blue and the top GRS decile in red, shown for different age groups. The corresponding dashed lines are regression lines of best fit.

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