Fig. 6: Effect of the ARHI variants on tinnitus.

The effect of the ARHI variants on ARHI is plotted against their effect on tinnitus for a all ARHI variants and b zoomed-in on variants from (a) with ARHI OR < 1.35. Effects are shown as the logarithm of the estimated odds ratios. ARHI variants detected under the additive model were tested for tinnitus using the additive model (blue dots) and ARHI variants detected under the recessive model were tested for tinnitus using the recessive model (red dots). The corresponding dashed lines represent results from a linear regression using MAF(1-MAF) as weights. Variants that affect tinnitus, controlling the false discovery rate at 0.05, are plotted with darker color and labeled with their corresponding gene. All effects are shown for the ARHI risk-increasing allele. Error bars represent 95% confidence intervals. The dotted lines represent results from a weighted linear regression using MAF(1-MAF) as weights, red for recessive variants and blue for additive, and the weighted correlation coefficients (r) and the corresponding P-values are shown in (a).