Table 2 Association of sequence variants with ARHI.

From: The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis

Model

P-value

OR

rs name

Chrom

Position

EA

OA

Gene

Variant annotation

EAF ice (%)

EAF UK (%)

A

5.7 × 10−27

4.20

–

17

75927880

  

FBF1*

CDS tdup

0.22

0

A

8.0 × 10−14

1.32

rs146694394

6

158071628

T

C

SYNJ2

Missense

0.37

0.46

A

1.8 × 10−13

1.28

rs141952919

7

103421378

G

A

SLC26A5

Missense

0.33

0.52

A

5.9 × 10−13

6.59

rs761934676

16

2497068

G

A

TBC1D24

Missense

0

0.01

A

5.1 × 10−11

1.08

rs113784020

11

118689022

T

C

[PHLDB1]

Intergenic

3.75

4.27

A

2.5 × 10−10

1.92

rs749405486

22

50549067

A

AG

KLHDC7B

Frameshift

0.00

0.06

A

4.9 × 10−13

0.95

rs72622588

3

182285702

T

G

[FLJ46066]

Intergenic

10.73

10.81

A

6.5 × 10−10

1.20

rs143796236

17

81528943

T

C

FSCN2*

Missense

0.21

0.74

A

7.6 × 10−10

1.03

rs13171669

5

149221680

G

A

ABLIM3

Intron

42.92

42.34

A

1.2 × 10−9

1.03

rs3014246

1

45620405

C

T

CCDC17

Missense

27.01

29.64

A

1.6 × 10−9

1.03

rs920701

13

75842965

C

T

LMO7

Intron

34.91

36.67

A

3.9 × 10−9

0.97

rs11881070

19

2389142

T

C

TMPRSS9

upstream gene

30.15

28.79

A

4.9 × 10−8

1.81

rs764272881

20

3228565

G

A

SLC4A11

Missense

0.45

0

A

4.1 × 10−8

71.17

rs765488721

17

61403195

T

C

TBX2*

Stop-gained

0.01

0

A

8.3 × 10−8

1.49

rs727503493

21

42389042

T

TG

TMPRSS3

Frameshift

0.22

0.07

R

1.7 × 10−22

3.65

rs118174674

18

46557437

T

C

LOXHD1

Missense

2.95

1.99

R

3.2 × 10−11

1.05

rs9394952

6

43433367

G

A

ABCC10

Splice region

49.99

48.13

R

7.7 × 10−11

2.35

rs12784122

10

80649861

A

G

SH2D4B*

Downstream gene

2.66

2.29

R

3.5 × 10−10

17.32

rs139123090

10

126459169

A

G

C10orf90*

Missense

0.89

0.47

R

3.2 × 10−9

0.94

rs557563970

1

117960109

CGT

C

WDR3

3 prime UTR

21.76

41.74

R

1.2 × 10−8

4.79

rs74543584

11

118262596

A

T

MPZL2

Missense

1.47

0.83

  1. OR odds ratio, Chrom chromosome, EA effect allele, OA other allele, EAF effect allele frequency, Ice Iceland, A additive model, R recessive model.The table lists the 21 variants revealed through the GWAS meta-analysis on ARHI. Gene names marked with * have not been linked to hearing, to the best of our knowledge. For intergenic variants, the nearest genes are reported in brackets. A likelihood-ratio test was performed in all genome-wide associations.
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