Fig. 7: PAG depletion in T cells is sufficient for an anti-tumor effect.
From: Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
MC38 tumors were implanted in WT mice that received two adoptive transfers of 8.5 × 106 WT or KO CD3+ T cells (six mice per group). a, b Daily tumor growth as calculated from measurement by digital caliper. Mean ± SEM (a); individual mice (b). c Immunohistochemical and quantification for granzyme B+ (GZMB) infiltrating cells in MC38 tumors from adoptive transfer recipient mice at day 26 after tumor implantation. ***p < 0.001; ****p < 0.0001.
