Fig. 5: GARFIELD functional enrichment analyses.
From: Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
The wheel plot shows functional enrichment for asthma variants within DNase I hypersensitivity site hotspot regions in ENCODE and Roadmap Epigenomics data. The radial axis represents the enrichment (OR) for each of 424 cell types that are sorted by tissue along the outside edge of the plot. Tissues are labeled with font size proportional to the number of cell types. Boxes forming the edge are colored by tissue. Enrichment is calculated for two GWAS significance thresholds: 1.0E−5 and 1.0E−8, which are plotted in blue and black, respectively, inside the plot. Dots along the inside edge of the plot are colored with respect to tissue and represent significant enrichment for a specific cell type (one dot = P < 1E−5 and two dots = P < 1E−6).
