Table 2 Deleterious coding SNPs associated with asthma or in LD with asthma-associated SNPs outside of the MHC locus.
From: Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
Chr | Chr band | rsID | PositionGRCh37 | PGWAS | Beta | CADD | Gene symbol | Gene name |
|---|---|---|---|---|---|---|---|---|
1 | 1p36 | rs2230624 | 12,175,658 | 1.99E−9 | −0.16 | 22.1 | TNFRSF8 | TNF receptor superfamily member 8 |
1 | 1q21 | rs61816761 | 152,285,861 | 3.95E−22 | 0.22 | 36 | FLG-AS1/ FLG | Filaggrin |
4 | 4p14 | rs11096957 | 38,776,491 | 2.49E−10 | −0.05 | 21.9 | TLR10 | Toll like receptor 10 |
5 | 5p15 | rs16903574 | 14,610,309 | 5.3E−12 | 0.09 | 22.6 | FAM105A/ OTULINL | OTU deubiquitinase with linear linkage specificity like |
11 | 11q13 | rs12146493 | 65,547,333 | 7.69E−6 | −0.03 | 22.2 | AP5B1 | Adapter related protein complex 5 subunit beta 1 |
12 | 12q21 | rs3763978 | 71,533,534 | 2.6E−10 | −0.04 | 24.5 | TSPAN8 | Tetraspanin 8 |
17 | 17q12 | rs1058808 | 37,884,037 | 1.94E−26 | −0.07 | 23.5 | ERBB2 | erb-b2 receptor tyrosine kinase 2 |
17 | 17q12 | rs1877031 | 37,814,080 | 4.71E−22 | −0.07 | 23.1 | STARD3 | StAR related lipid transfer domain containing 3 |
17 | 17q21 | rs3894194 | 38,121,993 | 7.95E−33 | 0.08 | 21.9 | GSDMA | Gasdermin A |
