Table 4 Genes prioritized as therapeutic targets for asthma in alphabetic order.

Genes	Lung TWAS gene	Blood eGene	Hi-C gene	Asthma score^a	DGIdb 3.0^b	Druggable genome^c	Asthma drug targets^d
*CCR4*	No	Yes	No	0.62	Yes	Yes	No
CCR7	No	Yes	Yes	0.55	No	Yes	Yes
CD247	No	Yes	Yes	1	Yes	Yes	Yes
ERBB2	No	Yes	Yes	0.51	Yes	Yes	No
ERBB3	No	Yes	Yes	0.62	Yes	Yes	Yes
FADS2	No	Yes	No	0.63	Yes	No	Yes
FASLG	No	No	Yes	0.84	No	Yes	No
FCER1G	Yes	No	No	0.64	Yes	No	Yes
GLB1	No	Yes	Yes	0.71	No	Yes	No
GPR18	No	Yes	Yes	0.50	Yes	Yes	No
GPR183	No	Yes	Yes	0.54	Yes	Yes	Yes
*IL13*	No	No	Yes	1	Yes	Yes	No
IL18R1	No	Yes	No	1	No	Yes	No
IL18RAP	No	Yes	No	0.57	No	Yes	Yes
IL1RL1	Yes	Yes	No	1	No	Yes	Yes
*IL2RA*	No	Yes	No	1	Yes	Yes	Yes
IL33	No	No	Yes	1	No	Yes	No
*IL4R*	Yes	Yes	Yes	1	Yes	Yes	Yes
*IL5*	No	No	Yes	1	Yes	Yes	No
*IL6*	No	Yes	Yes	1	Yes	Yes	No
IL7R	No	Yes	Yes	1	Yes	Yes	Yes
ITGB8	No	No	Yes	1	No	Yes	Yes
ITPR3	No	Yes	No	0.73	Yes	Yes	Yes
MYC	No	Yes	No	1	Yes	No	No
NDFIP1	No	Yes	No	0.80	No	Yes	Yes
NOTCH4	No	Yes	Yes	0.65	Yes	Yes	No
PLXNC1	No	Yes	Yes	1	No	Yes	No
PRKCQ	No	Yes	No	1	Yes	Yes	Yes
PTPRC	No	Yes	Yes	1	Yes	Yes	No
RORA	No	Yes	No	1	Yes	Yes	No
RORC	No	Yes	Yes	0.67	Yes	Yes	No
RUNX1	No	Yes	No	0.80	Yes	No	No
*SMAD3*	Yes	Yes	Yes	1	Yes	Yes	No
STAT6	No	Yes	No	1	Yes	Yes	Yes
TLR1	Yes	Yes	Yes	1	No	Yes	Yes
TLR10	No	Yes	Yes	0.94	No	Yes	No
TLR6	No	Yes	Yes	0.77	No	Yes	Yes
TNFRSF8	No	No	Yes	1	Yes	Yes	No
*TNFSF4*	No	Yes	Yes	1	Yes	Yes	Yes
*TSLP*	Yes	No	Yes	1	No	Yes	Yes

Quick links

Search