Fig. 2: RNA-editing profiles across brain regions.

a PCA on editing levels across 30 anatomically defined subregions. The subregions are as follows: olfactory bulb, ob; cingulate cortex, cg; motor cortex, mo; prefrontal cortex, pf; retrosplenial cortex, rt; somatosensory cortex, ss; temporal lobe, tp; insula cortex, in; occipital lobe, oc; amygdala, am; entorhinal cortex, en; hippocampus dorsal, hd; hippocampus ventral, hv; subiculum, sb; caudate nucleus, cn; putamen, pu; septum, sep; ventral pallidum, vp; hypothalamus, hy; thalamus, th; midbrain, mb; periaqueductal gray, pg; superior colliculus, sc; substantia nigra, sn; medulla oblongata, my; pons, po; cerebellum, cb; corpus callosum, cc; spinal cord dorsal, sd; and spinal cord ventral, sv. The 30 anatomically defined subregions are organized into 12 main regions. The regions are as follows: Olfactory bulb, OLF; Cerebral cortex, CTX; Amygdala, AMY; Hippocampal formation, HPF; Basal ganglia, BG; Hypothalamus, HY; Thalamus, TH; Midbrain, MB; Pons and medulla, PM; Cerebellum, CB; Corpus callosum, CC; and Spinal cord, SC. b, c Overall editing levels of coding (b) or repetitive (c) sites in brain regions. The number of biological replicates in each main region is as follows: OLF (n = 5), CTX (n = 31), AMY (n = 4), HPF (n = 16), BG (n = 16), HY (n = 4), TH (n = 4), MB (n = 15), PM (n = 8), CB (n = 4), CC (n = 4), and SC (n = 8). The dashed line denotes the median value of all regions. The significance of differences between overall editing level of each region and that of all regions was assessed by Wilcoxon’s test (*P ≤ 0.05 and **P ≤ 0.01). d The percentage of editing sites classified according to regional specificity. e Chord diagrams showing region-specific editing sites across 12 brain regions.